Wybutosine hypomodification of tRNAphe activates HERVK and impairs neuronal differentiation
Summary: We previously reported that loss of function of TYW1 led to cerebral palsy with severe intellectual disability through reduced neural proliferation.However, whether TYW1 loss affects neural differentiation is unknown.In this Wireless Keyboards study, we first demonstrated that TYW1 loss blocked the formation of OHyW in tRNAphe and therefor